Vol. 33, Issue 2-3, pp. 505-519

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  2. Optica Applicata Vol. 33, Issue 2-3, pp. 505-519 (2003)
Vol. 33 Issue 2-3 pp. 505-519

Investigation of photo-physical properties of selected diaminoacid protoporphyrin derivatives (PP(AA)2Arg2). II. Determination of quantum yield of singlet oxygen FD

Shu Ye, Miroslaw Kwasny, Mariusz Czuba, Alfreda Graczyk

Keywords

photosensitizers, photodynamic therapy, quantum yield of singlet oxygen

Abstract

A new generation of photosensitizers for photodynamic therapy (PDT) has been investigated. Different amino acids were bound to protoporphyrin (PP). Two methods of determination the quantum yield of generated singlet oxygen in porphyrin solutions were investigated. In the first method, tryptophan was used as a singlet oxygen acceptor. In the second one, the amount of singlet oxygen was determined by phosphorescence at 1272 nm. The purpose of this work was to evaluate the quantum yield of singlet oxygen of different PP(AA)2Arg2 derivatives, since it is crucial for choosing proper ingredients of photosensitizer for diagnosis and therapy in PDT.

Vol. 33
Issue 2-3
pp. 505-519

1.84 MB
OPTICA APPLICATA - a quarterly of the Wrocław University of Science and Technology, Faculty of Fundamental Problems of Technology