Vol. 33, Issue 2-3, pp. 505-519 (2003)

Abstract

A new generation of photosensitizers for photodynamic therapy (PDT) has been investigated. Different amino acids were bound to protoporphyrin (PP). Two methods of determination the quantum yield of generated singlet oxygen in porphyrin solutions were investigated. In the first method, tryptophan was used as a singlet oxygen acceptor. In the second one, the amount of singlet oxygen was determined by phosphorescence at 1272 nm. The purpose of this work was to evaluate the quantum yield of singlet oxygen of different PP(AA)₂Arg₂ derivatives, since it is crucial for choosing proper ingredients of photosensitizer for diagnosis and therapy in PDT.